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Global and United States Opioids Market Report & Forecast 2023-2028
1 Study Coverage
1.1 Opioids Product Introduction
1.2 Global Opioids Outlook 2017 VS 2022 VS 2028
1.2.1 Global Opioids Sales in US$ Million for the Year 2017-2028
1.2.2 Global Opioids Sales in Volume for the Year 2017-2028
1.3 United States Opioids Outlook 2017 VS 2022 VS 2028
1.3.1 United States Opioids Sales in US$ Million for the Year 2017-2028
1.3.2 United States Opioids Sales in Volume for the Year 2017-2028
1.4 Opioids Market Size, United States VS Global, 2017 VS 2022 VS 2028
1.4.1 The Market Share of United States Opioids in Global, 2017 VS 2022 VS 2028
1.4.2 The Growth Rate of Opioids Market Size, United States VS Global, 2017 VS 2022 VS 2028
1.5 Opioids Market Dynamics
1.5.1 Opioids Industry Trends
1.5.2 Opioids Market Drivers
1.5.3 Opioids Market Challenges
1.5.4 Opioids Market Restraints
1.6 Study Objectives
1.7 Years Considered
2 Market by Type
2.1 Opioids Market Segment by Type
2.1.1 Oxycodone
2.1.2 Hydromorphone
2.1.3 Codeine
2.1.4 Fentanyl
2.1.5 Other
2.2 Global Opioids Market Size by Type
2.2.1 Global Opioids Sales in Value, by Type (2017, 2022 & 2028)
2.2.2 Global Opioids Sales in Volume, by Type (2017, 2022 & 2028)
2.2.3 Global Opioids Average Selling Price (ASP) by Type (2017, 2022 & 2028)
2.3 United States Opioids Market Size by Type
2.3.1 United States Opioids Sales in Value, by Type (2017, 2022 & 2028)
2.3.2 United States Opioids Sales in Volume, by Type (2017, 2022 & 2028)
2.3.3 United States Opioids Average Selling Price (ASP) by Type (2017, 2022 & 2028)
3 Market by Application
3.1 Opioids Market Segment by Application
3.1.1 Pain Relief
3.1.2 Anesthesia
3.1.3 Cough Suppression
3.1.4 Diarrhea Suppression
3.1.5 Deaddiction
3.1.6 Others
3.2 Global Opioids Market Size by Application
3.2.1 Global Opioids Sales in Value, by Application (2017, 2022 & 2028)
3.2.2 Global Opioids Sales in Volume, by Application (2017, 2022 & 2028)
3.3.3 Global Opioids Average Selling Price (ASP) by Application (2017, 2022 & 2028)
3.3 United States Opioids Market Size by Application
3.3.1 United States Opioids Sales in Value, by Application (2017, 2022 & 2028)
3.3.2 United States Opioids Sales in Volume, by Application (2017, 2022 & 2028)
3.3.3 United States Opioids Average Selling Price (ASP) by Application (2017, 2022 & 2028)
4 Global Opioids Competitor Landscape by Company
4.1 Global Opioids Market Size by Company
4.1.1 Top Global Opioids Manufacturers Ranked by Revenue (2021)
4.1.2 Global Opioids Revenue by Manufacturer (2017-2022)
4.1.3 Global Opioids Sales by Manufacturer (2017-2022)
4.1.4 Global Opioids Price by Manufacturer (2017-2022)
4.2 Global Opioids Concentration Ratio (CR)
4.2.1 Opioids Market Concentration Ratio (CR) (2017-2022)
4.2.2 Global Top 5 and Top 10 Largest Manufacturers of Opioids in 2021
4.2.3 Global Opioids Market Share by Company Type (Tier 1, Tier 2, and Tier 3)
4.3 Global Opioids Manufacturing Base Distribution, Product Type
4.3.1 Global Opioids Manufacturers, Headquarters and Distribution of Producing Region
4.3.2 Manufacturers Opioids Product Type
4.3.3 Date of International Manufacturers Enter into Opioids Market
4.4 Manufacturers Mergers & Acquisitions, Expansion Plans
4.5 United States Opioids Market Size by Company
4.5.1 Top Opioids Players in United States, Ranked by Revenue (2021)
4.5.2 United States Opioids Revenue by Players (2020, 2021 & 2022)
4.5.3 United States Opioids Sales by Players (2020, 2021 & 2022)
5 Global Opioids Market Size by Region
5.1 Global Opioids Market Size by Region: 2017 VS 2022 VS 2028
5.2 Global Opioids Market Size in Volume by Region (2017-2028)
5.2.1 Global Opioids Sales in Volume by Region: 2017-2022
5.2.2 Global Opioids Sales in Volume Forecast by Region (2023-2028)
5.3 Global Opioids Market Size in Value by Region (2017-2028)
5.3.1 Global Opioids Sales in Value by Region: 2017-2022
5.3.2 Global Opioids Sales in Value by Region: 2023-2028
6 Segment in Region Level & Country Level
6.1 North America
6.1.1 North America Opioids Market Size YoY Growth 2017-2028
6.1.2 North America Opioids Market Facts & Figures by Country (2017, 2022 & 2028)
6.1.3 U.S.
6.1.4 Canada
6.2 Asia-Pacific
6.2.1 Asia-Pacific Opioids Market Size YoY Growth 2017-2028
6.2.2 Asia-Pacific Opioids Market Facts & Figures by Region (2017, 2022 & 2028)
6.2.3 China
6.2.4 Japan
6.2.5 South Korea
6.2.6 India
6.2.7 Australia
6.2.8 Taiwan
6.2.9 Indonesia
6.2.10 Thailand
6.2.11 Malaysia
6.2.12 Philippines
6.3 Europe
6.3.1 Europe Opioids Market Size YoY Growth 2017-2028
6.3.2 Europe Opioids Market Facts & Figures by Country (2017, 2022 & 2028)
6.3.3 Germany
6.3.4 France
6.3.5 U.K.
6.3.6 Italy
6.3.7 Russia
6.4 Latin America
6.4.1 Latin America Opioids Market Size YoY Growth 2017-2028
6.4.2 Latin America Opioids Market Facts & Figures by Country (2017, 2022 & 2028)
6.4.3 Mexico
6.4.4 Brazil
6.4.5 Argentina
6.5 Middle East and Africa
6.5.1 Middle East and Africa Opioids Market Size YoY Growth 2017-2028
6.5.2 Middle East and Africa Opioids Market Facts & Figures by Country (2017, 2022 & 2028)
6.5.3 Turkey
6.5.4 Saudi Arabia
6.5.5 U.A.E
7 Company Profiles
7.1 Teva
7.1.1 Teva Corporation Information
7.1.2 Teva Description and Business Overview
7.1.3 Teva Opioids Sales, Revenue and Gross Margin (2017-2022)
7.1.4 Teva Opioids Products Offered
7.1.5 Teva Recent Development
7.2 Purdue Pharma
7.2.1 Purdue Pharma Corporation Information
7.2.2 Purdue Pharma Description and Business Overview
7.2.3 Purdue Pharma Opioids Sales, Revenue and Gross Margin (2017-2022)
7.2.4 Purdue Pharma Opioids Products Offered
7.2.5 Purdue Pharma Recent Development
7.3 Mallinckrodt
7.3.1 Mallinckrodt Corporation Information
7.3.2 Mallinckrodt Description and Business Overview
7.3.3 Mallinckrodt Opioids Sales, Revenue and Gross Margin (2017-2022)
7.3.4 Mallinckrodt Opioids Products Offered
7.3.5 Mallinckrodt Recent Development
7.4 Amneal Pharma
7.4.1 Amneal Pharma Corporation Information
7.4.2 Amneal Pharma Description and Business Overview
7.4.3 Amneal Pharma Opioids Sales, Revenue and Gross Margin (2017-2022)
7.4.4 Amneal Pharma Opioids Products Offered
7.4.5 Amneal Pharma Recent Development
7.5 Collegium
7.5.1 Collegium Corporation Information
7.5.2 Collegium Description and Business Overview
7.5.3 Collegium Opioids Sales, Revenue and Gross Margin (2017-2022)
7.5.4 Collegium Opioids Products Offered
7.5.5 Collegium Recent Development
7.6 J&J
7.6.1 J&J Corporation Information
7.6.2 J&J Description and Business Overview
7.6.3 J&J Opioids Sales, Revenue and Gross Margin (2017-2022)
7.6.4 J&J Opioids Products Offered
7.6.5 J&J Recent Development
7.7 Endo
7.7.1 Endo Corporation Information
7.7.2 Endo Description and Business Overview
7.7.3 Endo Opioids Sales, Revenue and Gross Margin (2017-2022)
7.7.4 Endo Opioids Products Offered
7.7.5 Endo Recent Development
7.8 Pfizer
7.8.1 Pfizer Corporation Information
7.8.2 Pfizer Description and Business Overview
7.8.3 Pfizer Opioids Sales, Revenue and Gross Margin (2017-2022)
7.8.4 Pfizer Opioids Products Offered
7.8.5 Pfizer Recent Development
7.9 INSYS
7.9.1 INSYS Corporation Information
7.9.2 INSYS Description and Business Overview
7.9.3 INSYS Opioids Sales, Revenue and Gross Margin (2017-2022)
7.9.4 INSYS Opioids Products Offered
7.9.5 INSYS Recent Development
7.10 Mylan
7.10.1 Mylan Corporation Information
7.10.2 Mylan Description and Business Overview
7.10.3 Mylan Opioids Sales, Revenue and Gross Margin (2017-2022)
7.10.4 Mylan Opioids Products Offered
7.10.5 Mylan Recent Development
7.11 Hikma
7.11.1 Hikma Corporation Information
7.11.2 Hikma Description and Business Overview
7.11.3 Hikma Opioids Sales, Revenue and Gross Margin (2017-2022)
7.11.4 Hikma Opioids Products Offered
7.11.5 Hikma Recent Development
7.12 Egalet
7.12.1 Egalet Corporation Information
7.12.2 Egalet Description and Business Overview
7.12.3 Egalet Opioids Sales, Revenue and Gross Margin (2017-2022)
7.12.4 Egalet Products Offered
7.12.5 Egalet Recent Development
8 Industry Chain and Sales Channels Analysis
8.1 Opioids Industry Chain Analysis
8.2 Opioids Key Raw Materials
8.2.1 Key Raw Materials
8.2.2 Opioids Distributors
8.3 Opioids Production Mode & Process
8.4 Opioids Sales and Marketing
8.4.1 Opioids Sales Channels
8.4.2 Opioids Distributors
8.5 Opioids Customers
9 Research Findings and Conclusion
10 Appendix
10.1 Research Methodology
10.1.1 Methodology/Research Approach
10.1.2 Data Source
10.2 Author Details
10.3 Disclaimer
List of Tables
Table 1. Opioids CAGR in Value, United States VS Global, 2017 VS 2022 VS 2028
Table 2. Opioids Market Trends
Table 3. Opioids Market Drivers
Table 4. Opioids Market Challenges
Table 5. Opioids Market Restraints
Table 6. Global Opioids Sales by Type: 2017 VS 2022 VS 2028 (US$ Million)
Table 7. United States Opioids Sales by Type: 2017 VS 2022 VS 2028 (US$ Million)
Table 8. Global Opioids Sales by Application: 2017 VS 2022 VS 2028 (US$ Million)
Table 9. United States Opioids Sales by Application: 2017 VS 2022 VS 2028 (US$ Million)
Table 10. Top Opioids Manufacturers in Global Market, Ranking by Revenue (2021)
Table 11. Global Opioids Revenue by Manufacturer, (US$ Million), 2017-2022
Table 12. Global Opioids Revenue Share by Manufacturer, 2017-2022
Table 13. Global Opioids Sales by Manufacturer, (MT), 2017-2022
Table 14. Global Opioids Sales Share by Manufacturer, 2017-2022
Table 15. Global Opioids Price by Manufacturer (2017-2022) & (USD/Kg)
Table 16. Global Opioids Manufacturers Market Concentration Ratio (CR5 and HHI)
Table 17. Global Opioids by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Opioids as of 2021)
Table 18. Top Players of Opioids in Global Market, Headquarters and Distribution of Producing Region
Table 19. Manufacturers Opioids Product Type
Table 20. Date of International Manufacturers Enter into Opioids Market
Table 21. Manufacturers Mergers & Acquisitions, Expansion Plans
Table 22. Top Opioids Players in United States Market, Ranking by Revenue (2021)
Table 23. United States Opioids Revenue by Players, (US$ Million), 2020, 2021 & 2022
Table 24. United States Opioids Revenue Share by Players, 2020, 2021 & 2022
Table 25. United States Opioids Sales by Players, (MT), 2020, 2021 & 2022
Table 26. United States Opioids Sales Share by Players, 2020, 2021 & 2022
Table 27. Global Opioids Market Size by Region (US$ Million): 2017 VS 2022 VS 2028
Table 28. Global Opioids Sales in Volume by Region (2017-2022) & (MT)
Table 29. Global Opioids Sales in Volume Forecast by Region (2023-2028) & (MT)
Table 30. Global Opioids Sales in Value by Region (2017-2022) & (US$ Million)
Table 31. Global Opioids Sales in Value Forecast by Region (2023-2028) & (US$ Million)
Table 32. North America Opioids Sales in Volume by Country (2017-2028) & (MT)
Table 33. North America Opioids Sales in Value by Country (2017-2028) & (US$ Million)
Table 34. Asia Pacific Opioids Sales in Volume by Region (2017-2028) & (MT)
Table 35. Asia Pacific Opioids Sales in Value by Region (2017-2028) & (US$ Million)
Table 36. Europe Opioids Sales in Volume by Country (2017-2028) & (MT)
Table 37. Europe Opioids Sales in Value by Country (2017-2028) & (US$ Million)
Table 38. Latin America Opioids Sales in Volume by Country (2017-2028) & (MT)
Table 39. Latin Americaa Opioids Sales in Value by Country (2017-2028) & (US$ Million)
Table 40. Middle East and Africa Opioids Sales in Volume by Country (2017-2028) & (MT)
Table 41. Middle East and Africa Opioids Sales in Value by Country (2017-2028) & (US$ Million)
Table 42. Teva Corporation Information
Table 43. Teva Description and Business Overview
Table 44. Teva Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 45. Teva Opioids Product
Table 46. Teva Recent Development
Table 47. Purdue Pharma Corporation Information
Table 48. Purdue Pharma Description and Business Overview
Table 49. Purdue Pharma Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 50. Purdue Pharma Product
Table 51. Purdue Pharma Recent Development
Table 52. Mallinckrodt Corporation Information
Table 53. Mallinckrodt Description and Business Overview
Table 54. Mallinckrodt Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 55. Mallinckrodt Product
Table 56. Mallinckrodt Recent Development
Table 57. Amneal Pharma Corporation Information
Table 58. Amneal Pharma Description and Business Overview
Table 59. Amneal Pharma Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 60. Amneal Pharma Product
Table 61. Amneal Pharma Recent Development
Table 62. Collegium Corporation Information
Table 63. Collegium Description and Business Overview
Table 64. Collegium Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 65. Collegium Product
Table 66. Collegium Recent Development
Table 67. J&J Corporation Information
Table 68. J&J Description and Business Overview
Table 69. J&J Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 70. J&J Product
Table 71. J&J Recent Development
Table 72. Endo Corporation Information
Table 73. Endo Description and Business Overview
Table 74. Endo Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 75. Endo Product
Table 76. Endo Recent Development
Table 77. Pfizer Corporation Information
Table 78. Pfizer Description and Business Overview
Table 79. Pfizer Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 80. Pfizer Product
Table 81. Pfizer Recent Development
Table 82. INSYS Corporation Information
Table 83. INSYS Description and Business Overview
Table 84. INSYS Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 85. INSYS Product
Table 86. INSYS Recent Development
Table 87. Mylan Corporation Information
Table 88. Mylan Description and Business Overview
Table 89. Mylan Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 90. Mylan Product
Table 91. Mylan Recent Development
Table 92. Hikma Corporation Information
Table 93. Hikma Description and Business Overview
Table 94. Hikma Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 95. Hikma Product
Table 96. Hikma Recent Development
Table 97. Egalet Corporation Information
Table 98. Egalet Description and Business Overview
Table 99. Egalet Opioids Sales (MT), Revenue (US$ Million), Price (USD/Kg) and Gross Margin (2017-2022)
Table 100. Egalet Product
Table 101. Egalet Recent Development
Table 102. Key Raw Materials Lists
Table 103. Raw Materials Key Suppliers Lists
Table 104. Opioids Customers List
Table 105. Opioids Distributors List
Table 106. Research Programs/Design for This Report
Table 107. Key Data Information from Secondary Sources
Table 108. Key Data Information from Primary Sources
List of Figures
Figure 1. Opioids Product Picture
Figure 2. Global Opioids Revenue, (US$ Million), 2017 VS 2022 VS 2028
Figure 3. Global Opioids Market Size 2017-2028 (US$ Million)
Figure 4. Global Opioids Sales 2017-2028 (MT)
Figure 5. United States Opioids Revenue, (US$ Million), 2017 VS 2022 VS 2028
Figure 6. United States Opioids Market Size 2017-2028 (US$ Million)
Figure 7. United States Opioids Sales 2017-2028 (MT)
Figure 8. United States Opioids Market Share in Global, in Value (US$ Million) 2017-2028
Figure 9. United States Opioids Market Share in Global, in Volume (MT) 2017-2028
Figure 10. Opioids Report Years Considered
Figure 11. Product Picture of Oxycodone
Figure 12. Product Picture of Hydromorphone
Figure 13. Product Picture of Codeine
Figure 14. Product Picture of Fentanyl
Figure 15. Product Picture of Other
Figure 16. Global Opioids Market Share by Type in 2022 & 2028
Figure 17. Global Opioids Sales in Value by Type (2017-2028) & (US$ Million)
Figure 18. Global Opioids Sales Market Share in Value by Type (2017-2028)
Figure 19. Global Opioids Sales by Type (2017-2028) & (MT)
Figure 20. Global Opioids Sales Market Share in Volume by Type (2017-2028)
Figure 21. Global Opioids Price by Type (2017-2028) & (USD/Kg)
Figure 22. United States Opioids Market Share by Type in 2022 & 2028
Figure 23. United States Opioids Sales in Value by Type (2017-2028) & (US$ Million)
Figure 24. United States Opioids Sales Market Share in Value by Type (2017-2028)
Figure 25. United States Opioids Sales by Type (2017-2028) & (MT)
Figure 26. United States Opioids Sales Market Share in Volume by Type (2017-2028)
Figure 27. United States Opioids Price by Type (2017-2028) & (USD/Kg)
Figure 28. Product Picture of Pain Relief
Figure 29. Product Picture of Anesthesia
Figure 30. Product Picture of Cough Suppression
Figure 31. Product Picture of Diarrhea Suppression
Figure 32. Product Picture of Deaddiction
Figure 33. Product Picture of Others
Figure 34. Global Opioids Market Share by Application in 2022 & 2028
Figure 35. Global Opioids Sales in Value by Application (2017-2028) & (US$ Million)
Figure 36. Global Opioids Sales Market Share in Value by Application (2017-2028)
Figure 37. Global Opioids Sales by Application (2017-2028) & (MT)
Figure 38. Global Opioids Sales Market Share in Volume by Application (2017-2028)
Figure 39. Global Opioids Price by Application (2017-2028) & (USD/Kg)
Figure 40. United States Opioids Market Share by Application in 2022 & 2028
Figure 41. United States Opioids Sales in Value by Application (2017-2028) & (US$ Million)
Figure 42. United States Opioids Sales Market Share in Value by Application (2017-2028)
Figure 43. United States Opioids Sales by Application (2017-2028) & (MT)
Figure 44. United States Opioids Sales Market Share in Volume by Application (2017-2028)
Figure 45. United States Opioids Price by Application (2017-2028) & (USD/Kg)
Figure 46. North America Opioids Sales in Volume Growth Rate 2017-2028 (MT)
Figure 47. North America Opioids Sales in Value Growth Rate 2017-2028 (US$ Million)
Figure 48. U.S. Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 49. Canada Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 50. Europe Opioids Sales in Volume Growth Rate 2017-2028 (MT)
Figure 51. Europe Opioids Sales in Value Growth Rate 2017-2028 (US$ Million)
Figure 52. Germany Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 53. France Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 54. U.K. Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 55. Italy Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 56. Russia Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 57. Asia-Pacific Opioids Sales in Volume Growth Rate 2017-2028 (MT)
Figure 58. Asia-Pacific Opioids Sales in Value Growth Rate 2017-2028 (US$ Million)
Figure 59. China Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 60. Japan Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 61. South Korea Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 62. India Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 63. Australia Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 64. Taiwan Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 65. Indonesia Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 66. Thailand Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 67. Malaysia Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 68. Philippines Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 69. Latin America Opioids Sales in Volume Growth Rate 2017-2028 (MT)
Figure 70. Latin America Opioids Sales in Value Growth Rate 2017-2028 (US$ Million)
Figure 71. Mexico Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 72. Brazil Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 73. Argentina Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 74. Middle East & Africa Opioids Sales in Volume Growth Rate 2017-2028 (MT)
Figure 75. Middle East & Africa Opioids Sales in Value Growth Rate 2017-2028 (US$ Million)
Figure 76. Turkey Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 77. Saudi Arabia Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 78. U.A.E Opioids Sales in Value Growth Rate (2017-2028) & (US$ Million)
Figure 79. Opioids Value Chain
Figure 80. Opioids Production Process
Figure 81. Channels of Distribution
Figure 82. Distributors Profiles
Figure 83. Bottom-up and Top-down Approaches for This Report
Figure 84. Data Triangulation
Figure 85. Key Executives Interviewed
Please ask for List of Figures. Request Sample Report
Companies Included in Reports:
Teva Purdue Pharma Mallinckrodt Amneal Pharma Collegium J&J Endo Pfizer INSYS Mylan Hikma Egalet